One Heart World-Wide’s mission is to decrease maternal and neonatal mortality and morbidity in remote rural areas. Based on our experience, One Heart World-Wide developed an effective, replicable and sustainable model to reduce preventable deaths related to pregnancy and delivery among vulnerable rural populations. Simply put, we work with local communities and local health providers to develop a culturally appropriate Network of Safety around mothers and infants, by raising awareness, teaching good practices, and distributing essential supplies to ensure that mothers and infants survive delivery and the first months of life. The Network of Safety is innovative in that it is tailored to the local cultural context, that it puts the mother first and that our interventions are aimed simultaneously at several different levels to insure appropriate continuity of care for the mothers and infants. The demonstrated success of our model has lead us to expand our operations to other sites in need including the Baglung and Dolpo Districts in Western Nepal, and the Copper Canyon in the State of Chihuahua, Mexico.